^ a b c d e f "Flovent Diskus- fluticasone propionate powder, metered".^ a b c d e f g h "Flonase Allergy Relief- fluticasone propionate spray, metered".Ketoconazole, an antifungal drug, has also been shown to increase fluticasone concentration leading to systemic corticosteroid side effects. Coadministration of ritonavir and fluticasone may lead to increased levels of fluticasone in the body, which may lead to Cushing's Syndrome and adrenal insufficiency. Ritonavir is a common drug used in the treatment of HIV. Fluticasone propionate is stated to exert a topical effect on the lungs without significant systemic effects at usual doses, due to its low systemic bioavailability.įluticasone propionate is broken down by CYP3A4 (Cytochrome P450 3A4), and has been shown to interact with strong CYP3A4 inhibitors such as ritonavir and ketoconazole. histamine, eicosanoids, leukotrienes, and cytokines) involved in inflammation. mast cell, eosinophil, neutrophil, macrophages, and lymphocytes) and mediators (e.g. It has been shown to have a wide range of inhibitory effects on multiple cell types (e.g. ( January 2020) ( Learn how and when to remove this template message)įluticasone propionate is a highly selective agonist at the glucocorticoid receptor with negligible activity at androgen, estrogen, or mineralocorticoid receptors, thereby producing anti-inflammatory and vasoconstriction effects. Unsourced material may be challenged and removed. Please help improve this section by adding citations to reliable sources. These side effects include weakened immune system, increased risk of systemic infections, osteoporosis, and elevated pressure in the eyes. Using the spray or inhaler at higher than recommended doses or with other corticosteroids can increase the risk for serious, systemic corticosteroid induced side effects. However, systemic absorption is not negligible even with correct administration. If taken correctly, the nasal spray and oral inhaler formulation have fewer corticosteroid side effects than the tablet formulation because they limit systemic (blood) absorption. įluticasone propionate in a topical form can be used to treat skin conditions such as eczema, psoriasis, and rashes. The nasal spray can also be used in the mouth for mouth ulcers. Nasal drops are used in the treatment of nasal polyps. The nasal spray is used for prevention and treatment of allergic rhinitis. Medical uses įluticasone propionate is used by powder or aerosol inhalation for the prophylaxis of asthma. In 2020, fluticasone was the 23rd most commonly prescribed medication in the United States, with more than 24 million prescriptions. įluticasone propionate was patented in 1980, and approved for medical use in 1990. Common side effects when used in the nose include nosebleeding and sore throat. Ĭommon side effects when inhaled include upper respiratory tract infections, sinusitis, thrush, and cough. In the nose it is used for hay fever and nasal polyps. When inhaled it is used for the long term management of asthma and COPD. Fluticasone propionate, sold under the brand names Flovent and Flonase among others, is a steroid medication.
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